Berberine: ojiji, uru, mgbakwunye na mmetụta

Berberine nwere ogologo akụkọ ihe mere eme eji na usoro ọgwụgwọ ọdịnala, dịkaAyurvedana ọgwụ ndị East Asia. Ọ bụ kemịkalụ kemịkalụ na-atọ ụtọ nke sitere na osisi dị iche iche, dị ka hydrastis canadensis (goldenseal), coptis chinensis (coptis ma ọ bụ ọla edo) na berberis vulgaris (barberry). Nnyocha na-egosi na berberine nwere ike ịnwe ọgwụ nje na ọgwụ nje, yana mmetụta dị mma na metabolism, mana a ga-achọkwu ule ụlọ ọgwụ iji kwado uru ndị a.

Berberine nwekwara ike inwe ọtụtụ uru physiological na ọrụ ọgwụ na imeju, akụrụ, obi na ụbụrụ, nwere ike inye nkwado metabolic ọzọ. Dịka ọmụmaatụ, berberine na-arụ ọrụ enzyme AMP-activated protein kinase, nke nyocha na-egosi na-enyere aka ịhazi metabolism, ọrụ cell na ike ike.

A na-ejikarị Berberine eme ihe iji nyere akabelata shuga ọbara, melite ahụike obi, belata nrụgide oxidative nabelata cholesterol, yana maka mgbochi afọ ọsịsa, mgbochi mkpali na mgbochi ọrịa cancer, kwuru Heather Zwickey, Ph.D, prọfesọ nke immunology na National University of Natural Medicine na Portland, Oregon.

A na-ahụkarị Berberine n'ụdị capsule, mana a na-emepụta ya dị ka nsị anya na gels maka ọnọdụ mkpali dị iche iche nke akpụkpọ ahụ, anya ma ọ bụ nkwonkwo.

A na-eji ọtụtụ ihe ọkụkụ na ahịhịa ndị nwere berberine mee ọgwụ ọgwụ kemgbe ọtụtụ puku afọ, ma a chọkwuru nyocha iji ghọta usoro ihe mejupụtara ya na mmetụta dị ogologo oge. Site na nke ahụ, nyocha na-egosi na ọ nwere ike ịbara ahụike mmadụ uru n'ọtụtụ ụzọ.

Nwere ike inye aka belata shuga ọbara ma gbochie nguzogide insulin

Nyochaa 2022 inMoleculesegosi berberine nwere ike inye akabelata ọkwa glucose ọbaran'ihi na ọ na-abawanye mmepụta insulin ma na-eme ka mmetụta insulin dịkwuo mma, n'agbanyeghị na ọ dị mkpa nyocha ọzọ iji ghọta mmetụta ndị a nke ọma[1].

Nwere ike inye aka belata cholesterol

Nnyocha na-egosi na berberine nwere ike inwe mmetụta dị mma na yaLDL cholesterolna mkpokọta cholesterol, n'agbanyeghị na achọrọ nnwale ụlọ ọgwụ ọzọ iji ghọta nkwupụta ahụike a kpamkpam.

Nwere ike melite ahụike obi

Berberine nwere ike inwe mmetụta dị mma na anụ ahụ obi, karịsịa n'ọnọdụ nke ischemia (ọbara na-ezughị ezu), site n'ịme ka ike nke akwara obi dịkwuo mma, na-ebelata mbufụt, ibelata nrụgide oxidative, ibelata ọbara mgbali na ịba ụba nke mmepụta obi.

Nwere ike ịnwe mmetụta mgbochi mkpali

Berberine bụ alkaloid dị ilu nke na-enye mmetụta mgbochi mkpali sistemu, Alicia McCubbins, dọkịta naturopathic nke dabere na Vancouver, Washington kwuru. Ihe ndị a nwere ike ịba uru na usoro metabolic n'ozuzu, dị ka nwere ike inye aka na mgbochi nke atherosclerosis, ọrịa shuga 2, oke ibu na nsogbu obi. A mụọla ọgwụ mgbochi mkpali nke Berberine ogologo oge, mana aghọtabeghị usoro ọrụ ya, na-egosipụta mkpa maka nyocha ọzọ.

Nwere ike ịnwe Njirimara Antioxidant

Nyocha 2018 naFrontiers na Pharmacologyna-ekwubi na mmetụta antioxidant berberine yiri nke vitamin C, bụ antioxidant siri ike[2]. Ihe ndị dị ka vitamin C na berberine na-arụ ọrụ dị ka antioxidants iji nyere aka zere mmebi nke free radicals nwere ike ịkpata na sel.

Nwere ike ịnwe Njirimara Antibacterial na Antimicrobial

"Berberine nwere ihe astringent na a na-ewere ya dị ka antimicrobial eke nwere ike ịchụpụ nje bacteria, nje nje na fungi/candida," Dr. McCubbins na-ekerịta. Ihe ndị a na-egbochi nje nwere ike inye aka melite ọnọdụ ụfọdụ, dị ka nnukwuafọ ọsịsa, ọnyụnyụ ọbara, jaundice na ikpu na-efe efe, ọ bụ ezie na a chọkwuru nyocha iji kwado nkwupụta ndị a. Ọ bụrụ na mmadụ kwenyere na ha nwere ọrịa nje nke ụdị ọ bụla, ha kwesịrị ịkpọtụrụ onye nlekọta ahụike ha maka nyocha na ọgwụgwọ kwesịrị ekwesị tupu ha ewere berberine ma ọ bụ mgbakwunye ọ bụla ọzọ.

Nwere ike melite ahụike mgbari nri

Berberine nwere ike ịba uru maka mgbaze nri, dị ka afọ ntachi nanrekasi obi, dị ka Dr. McCubins si kwuo. "Alkaloids ndị a nwere ike inye uru bara uru na njikọ gut-ụbụrụ," ka ọ na-agbakwụnye, na-ekwusi ike mkpa njikọ dị n'etiti mgbaze, ọnọdụ na ahụike zuru oke.

Nwere ike ịkwado mbelata ibu na njikwa ibu

Berberine nwere ike inye aka belata nchekwa abụba na glucose site n'ịkwalite usoro metabolic, dị ka nbibi nke lipids (abụba) na shuga, nyocha na-atụ aro. Mmetụta dị mma Berberines nwere na eriri afọ microbiome nwekwara ike bụrụ akụkụ bụ isi na nkwado ya maka njikwa ibu.

Nwere ike melite akara ngosi nke ọrịa polycystic ovary (PCOS) na ịmụ nwa

Dị ka nyochaa naMolecules, na-ewere 1,500 milligrams nke berberine kwa ụbọchị maka ọnwa atọ na-ebelata ọkwa testosterone dị elu n'ime ụmụ nwanyị nwere nsogbu.PCOS[3]. Ọnọdụ a nwere ike ịgụnye ọkwa homonụ na-adịghị mma nke na-ebute ụzọ dị iche iche, na-ebute nsogbu dị ka obere cysts na ovaries ma ọ bụ nsọ nsọ. Ndị ọkachamara kwenyere na berberine na-eme ka nguzogide insulin dịkwuo mma, nke bụ ihe a na-ahụkarị na PCOS. Otú ọ dị, ndị na-eme nchọpụta na-atụ aro ka a chọkwuru ule ụlọ ọgwụ iji kwado mmetụta a nke berberine, gụnyere ogologo ọgwụgwọ na ọgwụgwọ ọgwụgwọ.

 

Kedu ka esi ewere Berberine?

Ihe mgbakwunye berberine dị n'ụdị capsule, mbadamba ma ọ bụ tincture, na-enye ohere maka usoro ọgwụgwọ ziri ezi yana oriri dị mfe. Capsules nwere ike ịka mma maka ọtụtụ ndị na-azụ ahịa n'ihi uto ya dị ilu, Dr. McCubins na-akọwa. "A na-ewerekarị Berberine dị ka tonic digestive 5 ruo 30 nkeji tupu nri. Berberine dị ilu n'ezie nke na-akpali ihe ọ juiceụụ gastric maka mgbaze na-arụ ọrụ nke ọma karị, "Ọ gara n'ihu na-aga n'ihu.

Usoro ọgwụgwọ Berberine

Ndị mmadụ n'otu n'otu kwesịrị ịkpọtụrụ onye na-ahụ maka ahụike ma ọ bụ onye na-ahụ maka ahịhịa iji kparịta usoro ọgwụgwọ ziri ezi (nke a na-ahazighị), wee gụọ ntuziaka onye nrụpụta, Dr. Zwickey kwuru. “A na-ewerekarị ya na ọ nweghị ihe ọ bụla na-ewere ya na ọ nweghị ihe karịrị gram 2 kwa ụbọchị. Iji nweta nsonaazụ kacha mma, mmadụ nwere ike chọọ iji opekata mpe 1 gram (1000 milligrams) kwa ụbọchị. Ọtụtụ ihe mgbakwunye [nwere] milligrams 500 kwa capsule, yabụ mmadụ ga-achọ ịnara [opekata mpe abụọ] capsules kwa ụbọchị,” ka ọ gara n'ihu.

Usoro onunu ogwu Berberine nwere ike dabere na ebumnuche ahụike onye ọ bụla. Banyere shuga ọbara, nyocha usoro 2019 na meta-analysis naAkwụkwọ akụkọ EndocrineAchọpụtara na ị na-ewere ihe na-erughị gram 2 nke berberine kwa ụbọchị maka ọnwa atọ nwere mmetụta dị mma na ọkwa glucose ọbara nke ndị sonyere na ụdị ọrịa shuga 2.[4].

Ka ọ dị ugbu a, nyocha nke nyocha dị naUsoro ọgwụgwọ agbakwunyere na Omume Clinicalnyochaa nzaghachi dose nke berberine wepụ maka ndị nwere oke ibu ma na-achọ njikwa ibu, na-achọpụta na dose nke 500 milligrams nke a na-ewere ugboro atọ n'ụbọchị mere ka mbelata.Oru uka index (BMI), okirikiri úkwù na ibu ahụ[5].

Mmetụta Berberine

Ihe mgbakwunye Berberine nwere ike inwe mmetụta ụfọdụ, gụnyere afọ ọsịsa, iwe iwe na isi ọwụwa, Dr. McCubins na-ekwu.

Ọ gara n'ihu ikwu, "Berberine na-arị elu na ewu ewu ma na-ere ya nke ukwuu na obodo ndị na-efunahụ ibu." "Kpachara anya ma kpọtụrụ dọkịta naturopathic gbasara ọgwụgwọ [nke berberine tupu iri ya]."

Ọ bụ ezie na a na-anabatakarị berberine nke ọma, ọ nwere ike ịkpata mgbu afọ na mgbakasị ahụ, afọ ntachi, afọ ọsịsa, flatulence, ọgbụgbọ na vomiting, Dr. Zwickey na-agbakwụnye.

Berberine ọ dị mma?

Nchekwa nchekwa bụ isi nke berberine bụ na ọ nwere ike iji ọtụtụ ọgwụ emekọrịta ihe, Dr. Zwickey na-ekwu. Mmekọrịta kachasị njọ bụ na cyclosporine, ọgwụ immunosuppressive nke a na-eji mgbe a na-atụgharị akụkụ ahụ yana iji nyere aka jikwaa ọnọdụ autoimmune dị ka.rheumatoid ogbu na nkwonkwo, dị ka berberine na-abawanye ntinye nke cyclosporine n'ime ọbara, ọ na-akọwa.

N'agbanyeghị ma mmadụ na-ewere berberine dị ka ihe mgbakwunye amịpụtara nke kwụ ọtọ ma ọ bụ n'ụdị herbl dum, ọ dị mkpa ịgbaso ntuziaka dose akwadoro nke onye nrụpụta ngwaahịa ma ọ bụ ọkachamara nlekọta ahụike nyere. A machibidoro Berberine maka ụmụaka, yana ndị dị ime na ndị na-enye nwa ara, Dr. Zwickey na-ekwu.

Kedu ihe ị ga-atụle mgbe ị na-azụta Berberine?

N'ihi na ọtụtụ ndị na-emepụta ihe na-eme ka berberine dị ọcha site na osisi, nyocha ụlọ nyocha nke atọ maka njirimara nke berberine, ike, àgwà na ịdị ọcha dị mkpa, Dr. Zwickey na-ekwu. "Mmadụ kwesịrị ịkpachara anya banyere ntinye mgbakwunye sitere na ụlọ ọrụ mgbakwunye ọkwa dibịa iji hụ na nnwale ndị ọzọ sitere na ụlọ ọrụ ndị a ma ama na mmesi obi ike maka ụkpụrụ [dosing] kacha mma," ka Dr. McCubbins na-agbakwụnye.

Ọ dịkwa mkpa ịhụ na a na-enweta berberine nke ọma, dịka Dr. McCubins siri kwuo. "Goldenseal, ọ bụ ezie na ọ bụ ezigbo isi iyi nke berberine, nọ n'ihe ize ndụ. Companieslọ ọrụ mgbakwunye a ma ama maara nke a [okwu],” ka ọ na-akọwa. Ọtụtụ aha mgbakwunye na-akọwapụta site na mkpuru osisi a na-ewepụta berberine.

Ebe ọ bụ na berberine enweghị ọmụmụ nchekwa nchekwa ogologo oge, mmadụ kwesịrị ịkpọtụrụ onye na-ahụ maka ahụike tupu ya agbakwunye berberine na usoro mgbakwunye ha iji hụ na ọ dabara na nchekwa maka mkpa ahụike ha pụrụ iche. Iji mụtakwuo maka uru ahụike berberine nwere ike, gwa dọkịta naturopathic, onye na-ahụ maka ahịhịa ma ọ bụ acupuncturist gbaara ezi àmà.